Cudurka kelyaha ee daba-dheeraada (CKD) bukaanku waxay inta badan qabaan hyperphosphatemia, iyo hyperphosphatemia muddada dheer waxay u horseedi kartaa dhibaatooyin halis ah sida hyperparathyroidism secondary, osteodystrophy kelyaha, iyo cudurrada wadnaha iyo xididada. Xakamaynta heerarka fosfooraska dhiigga waa qayb muhiim ah oo ka mid ah maaraynta bukaannada CKD, iyo xidhayaasha fosfooraska waa dawooyinka asaasiga ah ee daaweynta hyperphosphatemia. Sanadihii ugu dambeeyay,lanthanum carbonate, Sida nooc cusub oo aan kalsiyum iyo aluminium fosfateed ah, ayaa si tartiib tartiib ah u galay beerta aragtida dadka oo bilaabay "tartan" oo leh xirmooyinka fosfooraska dhaqameed.
"Mudnaanta" iyo "Demerits" ee xirmooyinka fosfatada dhaqameed
Xirayaasha fosfooraska dhaqameed inta badan waxaa ka mid ah xirayaasha fosfateetka ee ka kooban calcium (sida calcium carbonate iyo calcium acetate) iyo aluminium-ka kooban fosfatetada xirayaasha (sida aluminium hydroxide). Waxay ku daraan fosfooraska cuntada si ay u sameeyaan xeryahooda aan la milmi karin, taas oo yaraynaysa nuugista mindhicirka ee fosfooraska.
Kaalshiyam-ku-xidhayaasha fosfooraska-ka-kooban: Qiimo jaban iyo saameyn go'an oo fosfooraska-yareeya, laakiin isticmaalka muddada-dheer waxay u horseedi kartaa hypercalcemia waxayna kordhisaa khatarta xididdada dhiigga.
Aluminium-ka ku jira isku-xidhayaasha fosfooraska: Saamaynta xooggan ee hoos u dhigista fosfooraska, laakiin ururinta aluminiumku waa mid aad u sun ah waxayna sababi kartaa cudurrada lafaha aluminium ee la xidhiidha iyo encephalopathy, oo hadda aan la isticmaalin.
Lanthanum carbonate: Soogalootiga cusub ee soo koraya, oo leh faa'iidooyin muuqda
Lanthanum carbonate waa kaarboonaydh ka mid ah curiyaha birta dhulka dhifka ah ee lanthanum, oo leh hannaan xidhid fosfooraska u gaar ah. Waxay ku sii daysaa ions lanthanum deegaanka aysiidhka ah ee habka dheefshiidka waxayna samaysaa fosfate lanthanum fosfateed oo aad u liidata, taasoo ka hortagaysa nuugista fosfooraska.
Soo bandhigid kooban ee lanthanum carbonate
| Magaca alaabta | Lanthanum carbonate |
| Formula | La2 (CO3) 3.xH2O |
| CAS Maya. | 6487-39-4 |
| Miisaanka Molecular | 457.85 (anhy) |
| Cufnaanta | 2.6 g/cm3 |
| barta dhalaalaysa | N/A |
| Muuqashada | Budada crystal cad |
| Solubility | Ku milmay biyaha, si dhexdhexaad ah ugu milmay asiidhyada macdanta ee xooggan |
| Xasilooni | Si fudud hygroscopic |
Marka la barbardhigo xirmooyinka fosfooraska dhaqameed, lanthanum carbonate waxay leedahay faa'iidooyinka soo socda:
Ma jiro kalsiyum iyo aluminium, badbaado sare: Waxay ka fogaataa halista hypercalcemia iyo aluminium sumowga, gaar ahaan bukaanada leh daawaynta muddada dheer iyo halista calcification xididada.
Awood isku xidhka fosfooraska xooggan, saameyn weyn oo hoos u dhigista fosfooraska: Lanthanum carbonate waxay si wax ku ool ah ugu xidhi kartaa fosfooraska ee kala duwanaanta pH ballaaran, awooddeeda xidhidduna way ka xoog badan tahay xirayaasha fosfooraska dhaqameed.
Dareen-celinta xun ee caloosha iyo mindhicirka oo yar, u hoggaansanaanta wanaagsan ee bukaanka: Lanthanum carbonate dhadhamin wanaagsan, way fududahay in la qaato, waxay leedahay xanaaq yar oo caloosha ah, bukaanna waxay u badan tahay inay u hoggaansamaan daaweynta muddada-dheer.
Caddaynta cilmi-baarista kiliinikada: Lanthanum carbonate si fiican ayey u shaqeysaa
Daraasado caafimaad oo badan ayaa xaqiijiyay waxtarka iyo badbaadada lanthanum carbonate ee bukaanka CKD. Daraasaduhu waxay muujiyeen in lanthanum carbonate uusan ka hooseynin ama xitaa ka sarreyn xirmooyinka fosfooraska dhaqameed ee yareynta heerarka fosfooraska dhiigga, waxayna si wax ku ool ah u xakameyn karaan heerarka iPTH waxayna hagaajinayaan tilmaamayaasha dheef-shiid kiimikaadka lafaha. Intaa waxaa dheer, badbaadada daaweynta muddada-dheer ee lanthanum carbonate waa mid wanaagsan, mana jirto ururin cad oo lanthanum ah iyo falcelin sun ah oo la helay.
Daaweynta shakhsi ahaaneed: U dooro qorshaha ugu fiican bukaanka
Inkasta oo lanthanum carbonate leedahay faa'iidooyin badan, macnaheedu maaha in ay si buuxda u bedeli karto isku-xidhka fosfatada dhaqameed. Daawooyin kastaa waxay leeyihiin tilmaamo iyo iska-hor-imaadyo, qorshaha daawayntana waa in la shakhsiyeeyaa iyadoo loo eegayo xaaladda gaarka ah ee bukaanka.
Lanthanum carbonate waxay aad ugu habboon tahay bukaannada soo socda:
Bukaanka qaba hypercalcemia ama khatarta hypercalcemia
Bukaanka qaba calcification vascular ama halista calcification vascular
Bukaanka leh dulqaad liidata ama waxtarka liidata ee xirmooyinka fosfatada dhaqameed
Xirayaasha fosfooraska dhaqameed ayaa weli loo isticmaali karaa bukaannada soo socda:
Bukaanka leh xaalado dhaqaale oo xaddidan
Bukaannada xasaasiyadda u leh ama aan u dulqaadan karin lanthanum carbonate
Raadinta mustaqbalka: Lanthanum carbonate waxay leedahay mustaqbal ifaya
Iyadoo qoto dheer ee cilmi-baarista kiliinikada iyo ururinta waayo-aragnimada bukaan-socodka, heerka lanthanum carbonate ee daaweynta hyperphosphatemia ee bukaannada CKD ayaa sii wadi doona inay hagaajiyaan. Mustaqbalka, lanthanum carbonate ayaa la filayaa inay noqoto safka koowaad ee fosfatetada, taasoo war wanaagsan u keenaysa bukaanno badan oo CKD ah.
Waqtiga boostada: Mar-25-2025